Complete Diabetes Medications Table

2020 To quickly search this medication table hold Ctrl+f (windows) or Cmd+f (mac) and type your search term; hit enter. 

Related Links and Key

Diabetes Medication Classes

For quick access, click the medication class:

 

Alpha-Glucosidase Inhibitor

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Acarbose
Glucobay® (B) $24-$33
 50 or 100 mg
(100 mg tid)
Three times daily
(before meals)

Monotherapy or in combination with metformin, sulfonylurea or insulin



Biguanide (Metformin)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Metformin
Glucophage® (B) $4
 500 mg, 850 mg
‚Äč(max 2000-2500 mg/day) 
 
2-3 times daily 

Monotherapy or in combination with other antihyperglycemic agents

 Metformin extended release
Glumetza® (NB) $18-$74

500 mg, 1000 mg 
(max 2000 mg/day)
  Once daily   Monotherapy or in combination with other antihyperglycemic agents

 

DPP-4 Inhibitors

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
Alogliptin
Nesina® (NB) $66
  6.25 mg, 12.5 mg, 25 mg
(max 25 mg/day)
 Once daily
  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone or insulin.
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
Linagliptin
Trajenta® (SA) $79
5 mg
(max 5 mg/day)
Once daily

  • Monotherapy or in combination with metformin , sulfonylurea or with empagliflozin. 
  • Use of linagliptin with insulin may not be indicated in the product monograph, but is an acceptable combination according to research. 
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
  • Boehringer 6m compassionate supply form for MDs.
Saxagliptin
Onglyza® (SA) $75-$88 
 2.5 mg, 5 mg
(max 5 mg/day)
Once daily

  • In combination with metformin, sulfonylurea, dapagliflozin or insulin. 
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
 Sitagliptin
Januvia® (SA) $92 
25 mg, 50 mg, 100 mg
(max 100 mg/day)
Once daily 

  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone, dapagliflozin or insulin.
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
.

  

GLP-1 Agonists (Incretin Mimetics)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Dulaglutide injection
Trulicity® (NB) $203
0.75 mg, 1.5 mg
(max 1.5 mg/week)
Once weekly injection  Monotherapy or in combination with metformin, sulfonylurea or insulin. 
Exenatide ER (Extended Release)
Bydureon® (NB) $123
2 mg
(max 2 mg/week)
Once weekly injection Monotherapy or in combination with metformin, sulfonylurea or basal insulin. 
Exenatide ER (Extended Release)
Bydureon BCise® (NB); not yet marketed
                     2 mg                    (max 2 mg/week) Once weekly injection  Combination with metformin or sulfonylurea. 
 Exenatide
Byetta® (NB) $144
 5 mcg, 10 mcg
(max 20 mcg/day)
Twice daily injection  Add-on to metformin or sulfonylurea or glargine.  
 Liraglutide injection
Victoza® (NB) $91- $272
0.6 mg, 1.2 mg, 1.8 mg
(max 1.8 mg/day)
 Once daily injection  Monotherapy or in combination with metformin, sulfonylurea or basal insulin. Use with prandial insulin at DCC does not require note to prescriber. 
Lixisenatide injection
Adlyxine® (NB) $113
10 ug, 20 ug
(max 20 ug/day)
Once daily injection Monotherapy or use with metformin, sulfonylurea, pioglitazone or basal insulin.
Semaglutide injection
Ozempic® (SA) $195 
(NIHB Coverage -Non-insured health benefits for First Nations and Inuit)

 0.25, 0.5 mg, 1 mg
(max 1 mg/week) 
Once weekly injection  Monotherapy or in combination with metformin, sulfonylurea or basal insulin. Use with prandial insulin at DCC does not require note to prescriber.
Semaglutide tablets
Rybelsus® (NB) $219.44

3mg, 7 mg, 14 mg tablet

Once daily tablet

Monotherapy or in combination with other medicinal products for the treatment of diabetes (includes SGLT-2, secretagogues, metformin, insulins). 

To be taken on an empty stomach, at least 30 min before eating, with no more than 120 mL water. Review rationale here

Secretagogues (Sulfonylureas and Meglitinides)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Gliclazide
Diamicron® (B) $3 - $11
80 mg
(max 320 mg/day)
 Twice daily

 "Non- ketosis prone, maturity onset or adult type" diabetes
Gliclazide modified release
Diamicron MR® (B) $3 - $14
30 mg, 60 mg  
(max 120 mg/day)
Once daily 

"Non- ketosis prone, maturity onset or adult type" diabetes 
Glimepiride
Amaryl® (NB) $29-67
1 mg, 2 mg, 4 mg 
(max 8 mg/day) 
Once daily 

Monotherapy or with metformin or insulin
Glyburide
Diabeta® (B) $2-$6
2.5 mg, 5 mg 
(max 20 mg/day) 
Twice daily
 
Type 2 Diabetes 
Repaglinide
Gluconorm® (B) $7
0.5 mg, 1 mg, 2 mg 
(max 4 mg/meal; 16 mg/day)
At meals
(optional HS snack) 

Monotherapy or with metformin or rosiglitazone 

 SGLT-2 Inhibitors 

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Canagliflozin (SGLT 2)
Invokana® (SA) $84
 100 mg, 300 mg
(max 300 mg/day)
Once daily 
  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone, sitagliptin or insulin or as add-on combination in patients with established cardiovascular disease.
  • With type 2 diabetes and established cardiovascular disease to reduce the risk of major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and nonfatal stroke).
  • With type 2 diabetes and diabetic nephropathy to reduce the risk of end-stage kidney disease, doubling of serum creatinine, and cardiovascular (CV) death in adult patients with type 2 diabetes mellitus and diabetic nephropathy with albuminuria (>33.9 mg/mmol).
  • Use of other DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research. 
Dapagliflozin (SGLT 2)
Forxiga® (SA) $82
5 mg, 10 mg
(max 10 mg/day)
Once daily 
  • Monotherapy or in combination with metformin, sulfonylurea, sitagliptin or insulin or to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes and CV risk factors or established CV disease.
  • Use of other DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
 Empagliflozin (SGLT 2)
Jardiance® (SA) $81
10 mg, 25 mg
(max 25 mg/day)
Once daily  
  • Monotherapy or in combination with metformin, sulfonylurea, pioglitazone, linagliptin or insulin or as add-on combination in patients with established cardiovascular disease.
  • Use of other DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.
  • Boehringer 6m compassionate supply form for MDs.
Ertugliflozin (SGLT 2)
Steglatro® (NB) $74
5 mg, 15 mg
(max 15 mg/day)
Once daily (morning)
  • Monotherapy or in combination with metformin, sitagliptin.
  • Use of DPP-4 inhibitors with SGLT-2 inhibitors may not be outlined in the product monograph(s), but is an acceptable combination according to research.

Thiazolidinediones (TZDs)

Generic name
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Rosiglitazone
Avandia® (SA) $31 - $69
2 mg, 4 mg, 8 mg 
(max 8 mg/day)
Once daily

In combination with metformin or sulfonylurea. Prior to prescribing AVANDIA, physicians must: Document the eligibility of patients to meet the above criteria; Counsel each patient on the risks and benefits of AVANDIA, including the cardiovascular risks; and Obtain the patient’s written informed consent to take the drug. 
Pioglitazone
Actos® (SA) $10- $21
15 mg, 30 mg, 45 mg
(max 45 mg/day)
Once daily 

Monotherapy or in combination with metformin or sulfonylurea.

 

 Combination Medications

Generic name (class)
Brand names (*coverage) Cost/Month
 Available Strengths
(max daily dose)
Usual Dosing  Health Canada Indications
 Alogliptin (DPP-4) + Metformin
Kazano® (NB) $72
12.5 mg / 500 mg
12.5 mg / 850 mg
12.5 mg / 1000 mg
(max 25 mg + 2000 mg/day)
Twice daily Alone or in combination with pioglitazone or insulin 
Linagliptin (DPP-4) + Metformin
Jentadueto® (SA) $83
2.5 mg + 500 mg
2.5 mg + 850 mg
2.5 mg + 1000 mg
(max 5 mg + 2000 mg/day) 
Twice daily Alone or in combination with sulfonylurea or empagliflozin. 
Boehringer 6m compassionate supply form (MDs).
Sitagliptin (DPP-4) + Metformin
Janumet® (SA) $100
50 mg / 500 mg
50 mg / 850 mg
50 mg / 1000 mg 
(max 100 mg + 2000 mg/day)
Twice daily Alone or in combination with sulfonylurea, pioglitazone or insulin. 
Sitagliptin (DPP-4) + Metformin modified release
Janumet XR® (SA) $50 - $99
50 mg / 500 mg
50 mg / 1000 mg
100 mg / 1000 mg 
(max 100 mg + 2000 mg/day)

Once daily with a meal preferably in the evening 

Alone or in combination with sulfonylurea, pioglitazone or insulin. 
Sitagliptin (DPP-4) + Ertugliflozin (SGLT-2) Steglujan® (NB) No cost available             100 mg / 5 mg              100 mg / 15 mg  Once daily  Metformin 
Saxagliptin (DPP-4) + Metformin 
Komboglyze® (SA) $76
2.5 mg + 500 mg
2.5 mg + 850 mg
2.5 mg + 1000 mg
(max 5 mg + 2000 mg/day)  
 Twice daily  Alone or in combination with sulfonylurea or insulin.
Saxagliptin (DPP-4) + Dapagliflozin (SGLT-2) 
QTERN® (NB) $ - cost not available; not yet marketed
5 mg / 5 mg
5 mg / 10 mg 
(max 5 mg / 10 mg/day)
Once daily On metformin and saxagliptin alone or
 already controlled with metformin, saxagliptin and dapagliflozin. Can be used with insulin. 
Canagliflozin (SGLT-2) + Metformin
Invokamet® (NB) $95
50 mg / 500 mg
50 mg / 850 mg
50 mg / 1000 mg 
150 mg / 500 mg
150 mg / 850 mg
150 mg / 1000 mg 
(max 300 mg + 2000 mg/day)
Twice daily  Alone or in combination with sulfonylurea, pioglitazone or insulin.
Canagliflozin (SGLT-2) + Metformin modified release
Invokamet XR® (NB); not yet marketed 
50 mg / 500 mg
50 mg / 1000 mg 
150 mg / 500 mg
           150 mg / 1000 mg             (max 300 mg + 2000 mg/day)
Once daily  Alone or in combination with sulfonylurea, pioglitazone or insulin.
Dapagliflozin (SGLT-2) + Metformin
Xigduo® (SA) $74
5 mg / 850 mg
5 mg / 1000 mg
(max 10 mg + 2000 mg/day)
Twice daily  Alone or in combination with sulfonylurea, sitagliptin or insulin. 
Empagliflozin (SGLT-2) + Metformin
Synjardy® (NB) $83
5 mg / 500 mg
5 mg / 850 mg
5 mg / 1000 mg 
12.5 mg / 500 mg
12.5 mg / 850 mg
12.5 mg / 1000 mg
(max 25 mg + 2000 mg/day)
Twice daily 

 Alone or in combination with sulfonylurea, pioglitazone or insulin (not premix).

Boehringer 6m compassionate supply form (MDs).

Empagliflozin (SGLT-2) + Linagliptin (DPP-4)
Glyxambi® (NB) $142
10 mg / 5 mg
25 mg / 5 mg
(max 25 mg + 5 mg/day) 
Once daily  Metformin 
Ertugliflozin (SGLT-2) + Metformin Segluromet® (NB) $74    2.5 mg / 500 mg
2.5 mg / 1000 mg
7.5 mg / 500 mg
7.5 mg / 1000 mg
(max 15 mg / 2000 mg )          
Twice daily  Sitagliptin 
Insulin degludec + liraglutide (GLP-1)
Xultophy® (NB) $185-309

1 unit of Xultophy contains 1 unit of degludec and 0.04 mg liraglutide (fixed ratio)

Starting dose: 16 units
Maximum dose: 50 units

Once daily injection
  • Type 2 diabetes in combination with metformin, with or without sulfonylurea, when these combined with basal insulin (< 50 units daily) or liraglutide (less than or equal to 1.8 mg daily), do not provide adequate glycemic control.
 Insulin glargine + lixisenatide (GLP-1)
Soliqua®  (NB) $228 at max dose
(NIHB Coverage - Non-insured health benefits
for First Nations and Inuit)

1 unit of SOLIQUA contains 1 unit of insulin glargine and 0.33 mcg lixisenatide (fixed ratio)

Starting dose: 15 units/day or 30 units/day
Maximum dose:  60 units/day
 Once daily injection
  • Type 2 diabetes on basal insulin (< 60 units daily and > 15 units per day) alone or in combination with metformin
  • Taken before the first meal.
  • Starting Doses: 15 units Soliqua  (if current glargine dose < 30 units); 30 units Soliqua (if current glargine dose 30 to <60 units.)
  • Take oral contraceptives at least 1 hour before or at least 11 hours after the dose of SOLIQUA.
  • Suggested adjustments by fasting glucose of past 3 days:
    > 7.8 mmol/L add 4 units
    > 5.6 to < 7.8 mmol/L add 2 units
    4.4 to 5.6 mmol/L, no change
    < 4.4 mmol/L subtract 2 units

  

Insulins

For quick access, click the type of insulin. Or,  hold Ctrl+f (windows) or Cmd+f (mac) and type your search term; hit enter.

 

 Bolus Insulins

Pharmacodynamic action bolus insulins

Titration of Bolus Insulin: See Diabetes Canada Insulin Titration Regimens and our Insulin Adjustments webpage

 

Generic name
Brand names (*coverage) Cost/box

 Pharmacodynamics
Onset/Peak/Duration
Discard after room temp  Dosing Considerations
Aspart 
Novorapid® (B)
vial $30; cartridges $61;  prefills $64

Novorapid 

10-20 min / 1-3 hrs / 3-5 hrs

 28 days
  • May inject up to 10 minutes before a meal 
Faster Insulin Aspart
Fiasp® (coverage under review)
vial $30, cartridges $61, prefills $63 

Fiasp 

5-15 min / 1-3 hrs / 3-5 hrs

 28 days
  • May inject 2 mins before meal and up to 20 mins after starting meal
  • Should not be mixed with other insulins
  • Onset is 5 mins earlier than insulin aspart
  • Time to peak is 11mins faster than insulin aspart
  • Offset of effect occurs 12-14 mins earlier than insuilin aspart

Lispro 100 u/mL
Admelog® (NB) 
vial $NA; cartridges $NA; prefills $NA

30-45 min/ 1-3 hr / 3-5 hr  28 days  
Lispro 100 u/mL
Humalog® (B)
vial $29; cartridges $58; prefills $57

Humalog100or200u 

30-45 min / 1-3 hr / 3-5 hrs

28 days 
  • Available in 1/2 unit disposable pens with thebrand name "Humalog Junior KwikPen" 
Lispro 200 u/mL
Humalog® (B)
prefills $107

Same as Lispro 100 u/mL 

30-45 min / 1-3 hr / 3-5 hrs

28 days
  • Reserved for patients using > 20 units per day of rapid insulin.
  • Not to be mixed with other insulins
  • Not to be administered via SC infusion pump (not tested)
Glulisine
Apidra® (B)
vial $28; cartridges $53;  prefills $53

Apidra 

10-15 min / 1-1.5 hrs / 3-5 hrs

 28 days
  • Must not be refrigerated once opened
Regular Insulin
Humulin R® (B)
vial $24; cartridges $47

Refer to "regular insulin" line in the image Pharmacodynamic Action Profiles of Bolus Insulins 

30-60 min / 2-4 hrs / 6-8 hrs 

28 days  
Regular Insulin
 Novolin ge Toronto® (B)
vial $24; cartridges $47

Refer to "regular insulin" line in the image Pharmacodynamic Action Profiles of Bolus Insulins 

30-60 min / 2-4 hrs / 6-8 hrs

One month  
Insulin, human biosynthetic
Entuzity® (NB) 500 u/mL - acts as bolus and basal. See in the Basal Insulin Chart below. 
See in basal chart below 28 days  

  Basal Insulins

Pharmacodynamics long acting insulins

Generic name
Brand names (*coverage) Cost/box

Pharmacodynamics
Onset/Peak/Duration
Discard after room temp  Dosing Considerations
Degludec
Tresiba® (B) 2 concentrations
 100 u/mL: prefills $111
200 u/mL: prefills $133
Also see Combination Medications

Tresiba

1 hr / no peak / 42 hrs

8 weeks 
  • Doses dialed are per one "normal" unit; e,g,  80 units u100 = 80 units u200; the latter is contained in less volume. 
  • U100 pen delivers doses in 1 unit increments up to 80 unit per dose
  • U200 pen delivers doses in 2 unit increments up to 160 unit increments
  • Missed doses may be taken when remembered if at least 8 hrs between doses.
  • Steady state serum concentration is reached after 3-4 days. 
  • Diabetes Canada titration suggestions: 2 units every 3-4 days or 4 units a week. You may wish to use the  Tresiba titration handout
  • Reduce by 20% if patient has type 1 diabetes or if switching from bid basal
  • Also available as the combination medication  Xultophy® (degludec + liraglutide). See combination medications section
 Detemir 
Levemir® (B)
 cartridges $108; prefills $111

  Levemir

1.5 hrs /  no peak / 16-24 hrs

42 days 
(6 weeks)


Insulin, human biosynthetic
(basal and/or bolus)
Entuzity® (NB) 500 u/mL
prefills 2/box $94
prefills 5/box $237
(each pen has 1500 units)

Entuzity15 15 min / 4-8  hrs / 17-24 hrs

28 days 

 

  • Indicated for those requiring over 200 units insulin/day
  • Onset similar to U-100
  • Peak slightly lower than Humulin R U100
  • Time to peak is delayed (vs. Humulin R)
  • Dose 30 minutes before meal
  • Given 2-3 times daily
  • When switching to Entuzity and HbA1c < 8% reduce TDD by 20%
  • Pen delivers 5 unit increments
Insulin, human biosynthetic
Humulin N ® (B)
vial $24; cartridges $47; prefills $47

Humulin N 

1-2 hrs / 5-8 hrs / 14-18 hrs

28 days   
Insulin, human biosynthetic
Novolin ge NPH® (B)
vial $24; cartridges $48

Refer to NPH line in the image Pharmacodynamic Action Profiles of Long-Acting Insulins 

1-2 hrs / 5-8 hrs / 14-18 hrs

 One month  
Glargine
Lantus® (NB on July 1, 2020)
vial $62; cartridges $93; prefills $93
Also see Combination Medications for Soliqua®

Lantus 

1.5 hrs / no peak / 24 hrs

28 days 
  •  Reduce by 20% when switching from Toujeo to Lantus.
Glargine
Basaglar® (B)
cartridges $69; prefills $69

Basaglar 

1.5 hrs / no peak / 24 hrs

 28 days  
Glargine 300 u/mL
Toujeo® (NB)
1.5 mL (450 unit) prefilled SoloSTAR pens $79 

Toujeo 

up to 6 hrs / no peak / up to 36 hrs

42 days
(6 weeks) 
  • The prescribed dose of TOUJEO should always be expressed in units of insulin.
  • See Toujeo dosing handout.
  • Pen dials up to 80 units. Dials in one unit increments.
Glargine 300 u/mL 
Toujeo Doublestar
3 mL (900 unit) prefilled pens
$52.86 per each pen.

Toujeo

up to 6 hrs / no peak / up to 36 hrs

42 days
(6 weeks)
  • The prescribed dose of TOUJEO should always be expressed in units of insulin.
  • See Toujeo dosing handout.
  • Pen dials up to 160 units. Dials in two unit increments.

 

  Mixed Insulins

Generic name
Brand names (*coverage) Cost/Month
Pharmacodynamics
Onset/Peak/Duration
Discard after room temp (days) Dosing Considerations
Lispro insulin (% Humalog)/ lispro protamine 
Humulin® Mix25 (B) 
Cartridges $59, Prefills $58

Humulin® Mix50 (B) 
Cartridges $58, Prefills $57

Per insulins lispro (Humalog) and N   28 days

30% regular insulin (R) / 70% insulin isophane (N), 
Humulin®  30/70 (B)
vial $24, cartridges $47
Per insulins R and N  28 days  

 Regular insulin (%Toronto) / insulin (%NPH)
Novolin® ge 30/70 (B)
vial $24, cartridges $46

Novolin® ge 40/60 (B)
cartridges $46

Novolin® ge 50/50 (B) 
cartridges $46

Per insulins Toronto and NPH   1 month  
30% soluble insulin aspart (rapid)/
 70% insulin aspart protamine crystals (NPH)
NovoMix® 30 (NB)
cartridges $56
Per insulins aspart (Novorapid) and NPH  1 month  

 

Glucagon

Generic name
Brand names (*coverage) Cost/Month
Storage Supporting materials and other considerations
glucagon nasal powder
BAQSIMI™
Over $132 (detailed cost pending)
Store BAQSIMI in the shrink wrapped tube at temperatures up to 30°C (86°F).
glucagon injection
Glugagon Lilly (B)
$96 per one kit
Prior to reconstitution, Vials of GLUCAGON and prefilled Hyporets of Diluting Solution may be stored at controlled room temperature, 15° to 30°C
glucagon injection
GlucaGen® NovoNordisk (B)
$84.41 per one kit
Prior to reconstitution, the shelf life of the product is 3 years. GlucaGen® should be stored at a temperature not exceeding 2-8°C. The sealed container should be protected from light and freezing should be avoided.
     

 

 

*Verify Alberta Blue Cross coverage through their database